What this trial means for you
This study is recruiting now at 1 US site. It's studying Semaglutide Pen Injector [Ozempic], Placebo semaglutide pen injector for pre diabetes, postpartum disorder.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
The purpose of the study is to determine the efficacy of semaglutide 1mg (Ozempic®) to aid recently postpartum women with dysglycemia and a history of GDM to regress to normoglycemia; thereby filling a gap in efficacious pharmacologic intervention options for clinicians to support postpartum diabetes recovery and reduce future risk of T2DM in young women.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: 1. Female 2. 18 - 45 years old (inclusive) 3. History of gestational diabetes in most recent pregnancy 4. 6 months - 10 years postpartum 5. BMI ≥ 25 kg/m2 6. Use of long-acting reversible contraception or bilateral tubal ligation 7. Dysglycemia as determined by glycemic response to 75g, 2-hour OGTT: either impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or both (IFG/IGT): 1. Fasting glucose 100-125mg/dL (inclusive) and/or 2. 120 minute glucose 140-199mg/dL (inclusive) 8. Willingness to maintain physical activity level throughout study duration 9. Willingness to standardize diet for 3 days prior to OGTT 10. Ability to provide informed consent before any trial-related activities Exclusion Criteria: 1. Body weight \> 350lb 2. Pregnant or the intention of becoming pregnant or not using adequate contraceptive measures. 3. Breastfeeding within 3 months of screening visit 1 4. Post-menopausal 5. Desiring pregnancy within study participation period or two months after participation ends (i.e. 10 months from enrolment) 6. Use of tobacco products within past 6 months 7. Substance or alcohol abuse 8. Presence of significant systemic disease including: diabetes mellitus (type 1 or type 2), cardiac disease (e.g. congestive heart failure), renal impairment (e.g. serum creatinine levels ≥ 1.4 mg/dL or eGFR \< 60), hepatic disease (including viral hepatitis, toxic hepatic damage, jaundice of unknown aetiology, or abnormal liver function tests), pancreatitis, uncontrolled thyroid disease (e.g. documented abnormal TSH), adrenal disease (including Cushing's syndrome, congenital adrenal hyperplasia), hyperlipidemia (fasting triglycerides \> 399mg%), untreated or poorly controlled hypertension (resting blood pressure \>159/94 mmHg) 9. History of or presence of: eating disorder, malignant disease requiring chemotherapy, or debilitating psychiatric disorder such as psychosis or neurological condition that could confound outcome variables 10. History of bariatric surgery 11. Use of medications for glucose regulation: insulin (e.g. Humalog, Novolog, Humulin), pramlintide, metiglinides, metformin, thiazolidinediones, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT2 inhibitors within four weeks of screening visit 1 12. Use of medications for anti-obesity or weight loss within four weeks of screening visit 1 13. Use of medications known to exacerbate glucose dysfunction (such as isotretinoin or corticosteroids) within four weeks of screening visit 1 14. Known or suspected allergy to trial medication, excipients, or related products 15. Contraindications to study medications: patients with a personal or family history of medullary thyroid cancer or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) 16. Current or recent past (within 3 months) participation in another experimental drug trial 17. Previous randomization in this trial 18. Receipt of any investigational drug within 6 months prior to this trial
Study sites by state
Louisiana
- Woman's Hospital — Baton Rouge · Recruiting now
View the official record on ClinicalTrials.gov →
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