What this trial means for you
This study is active, not recruiting — it is not currently taking new participants, but its results may matter for treatments you're considering. It's studying see the official record for type 2 diabetes.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
Diabetes is a disorder of high blood glucose, that tends to get worse; over time, patients need more and more drugs. This pattern is caused by overwork of the body's insulin-producing β-cells, because patients' glucose levels are typically above normal; if the investigators kept glucose levels normal - reducing β-cell work - the investigators might be able to keep the disease from getting worse. This trial is aimed to show that adjusting the drugs to keep glucose levels normal, can help to preserve β-cell function compared to usual diabetes care, possibly reduce the tendency to develop the eye and kidney complications of diabetes, and might also be more cost-effective than usual care.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * diagnosis of diabetes by OGTT * age 40-75 years * HbA1c 6.0-7.4% * 1 hr OGTT glucose \>155 mg/dl in each group Exclusion Criteria: * CVD event during the previous year * systemic glucocorticoids * bariatric surgery * stage III-IV congestive heart failure * severe angina * life expectancy \<5 years * BMI \>40 kg/m2 * pregnancy * pancreatitis * family or personal history of multiple endocrine neoplasia 2a * an estimated glomerular filtration rate \[eGFR\] of ≤50 ml/min * an alanine aminotransferase (ALT) level \>3x the upper limit of the normal range * dementia
Study sites by state
Georgia
- Atlanta VA Medical Center — Decatur
View the official record on ClinicalTrials.gov →
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