What this trial means for you
This study is active, not recruiting — it is not currently taking new participants, but its results may matter for treatments you're considering. It's studying Semaglutide, Placebo for obesity.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
This study will look at how well semaglutide helps children and teenagers losing weight. This will be tested by comparing the effect on body weight in children and teenagers taking semaglutide in comparison to placebo, a "dummy" medicine. In addition to taking the medicine, the child's parent and the child will have talks with study staff about healthy food choices, how to be more physically active and what your child can do to try to lose weight. The child will either get semaglutide or a "dummy" medicine. Which treatment the child will get is decided by chance. Semaglutide is an approved medicine for type 2 diabetes and weight management in adults. The child will get one injection once a week. The study medicine is injected with a thin needle in the stomach, thighs or upper arms. The study will last for about 2 ½ years (132 weeks).
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Informed consent of parent(s) or legally acceptable representative (LAR) of participant and child assent, as age-appropriate, obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study. a) The parents or LAR of the child must sign and date the Informed Consent Form (according to local requirements) b) The child must sign and date the Child Assent Form or provide oral assent (according to local requirements) * Age at the time of signing informed consent. a)Group Kids: 6 to less than 12 years. b) Group Teens: 12 to less than 18 years and Tanner stage greater than 1 * Body mass index (BMI), at screening and randomisation, corresponding to a) Group Kids: greater than or equal to 95th percentile. b) Group Teens: greater than or equal to 95th percentile or greater than or equal to 85th percentile with the presence of at least 1 weight-related comorbidity (treated or untreated): hypertension, dyslipidaemia, obstructive sleep apnoea or type 2 diabetes mellitus (T2D) * History of at least one unsuccessful effort to lose sufficient body weight after participation in a structured lifestyle modification programme (diet and exercise counselling) for at least 3 months * Body weight of greater than 45 kilogram (kg) at screening and randomisation * For participants with T2D at screening, the following additional criterion applies: glycated haemoglobin (HbA1c) less than or equal to 10.0 percent (86 millimoles per mole \[mmol/mol\]) as measured by central laboratory at screening Exclusion Criteria: * Treatment with any medication prescribed for the indication of obesity or weight management within 90 days before screening * Previous or planned (during the study period) obesity treatment with surgery or a weight loss device. However, the following are allowed: a) liposuction and/or abdominoplasty, if performed greater than 1 year prior to screening. b) adjustable gastric banding, if the band has been removed greater than 1 year prior to screening. c) intragastric balloon, if the balloon has been removed greater than 1 year prior to screening. d)duodenal-jejunal bypass liner (e.g., nonbarrier), if the sleeve has been removed greater than 1 year prior to screening * Type 1 diabetes mellitus or monogenic diabetes * Participants with endocrine, hypothalamic, or syndromic obesity * For participants with T2D at screening, the following additional key criterion applies: Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within the past 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination
Study sites by state
California
- Neighborhood Healthcare — Escondido
Connecticut
- Yale School of Medicine — New Haven
Georgia
- Columbus Research Foundation — Columbus
- Eastside Bariatric and Gen Surg — Snellville
Idaho
- Solaris Clinical Research — Meridian
Louisiana
- Pennington Biom Res Ctr — Baton Rouge
- Clinical Trials of America LLC — Monroe
- IMA Clinical Research — Monroe
Maryland
- Barry J. Reiner, MD LLC — Baltimore
Massachusetts
- Massachusetts General Hospital_Cary — Boston
Minnesota
- University of Minnesota — Minneapolis
Mississippi
- Mississippi Center for Advanced Medicine — Madison
- Mississippi CTR for ADV MED — Madison
New York
- UBMD Peds-Div of Endo/Diabetes — Buffalo
North Carolina
- WakeMed Childn Endo-Dbt_Raleig — Raleigh
North Dakota
- Valley Weight Loss Clinic — Fargo
Ohio
- Centricity Research - Ohio — Columbus
Pennsylvania
- UPMC Child Hosp-Pittsburgh — Pittsburgh
Tennessee
- Vanderbilt University Medical Center — Nashville
- Pediatric Clinical Trials, LLC — Tullahoma
Texas
- Texas Diabetes & Endocrinology — Austin
- Univ Of Texas Hlth Science Cntr — San Antonio
Virginia
- Health Res of Hampton Roads — Newport News
Wisconsin
- Marshfield Clinic — Marshfield
View the official record on ClinicalTrials.gov →
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