What this trial means for you
This study is active, not recruiting. It is not currently taking new participants, but its results may matter for treatments you're considering. It's studying Orforglipron, Placebo for obesity, overweight, overweight or obesity.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study, ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
This study will investigate the efficacy and safety of once daily oral orforglipron in adult participants with obesity or overweight with weight-related comorbidities. The study has two phases: a main phase and an extension phase. The main phase of the study lasted 72 weeks. Participants with prediabetes will continue in the extension for another 2 years.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry. Bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Have a BMI * ≥30.0 kilogram/square meter (kg/m²), * ≥27.0 kg/m² and presence of at least 1 of the following weight-related comorbidities (treated or untreated) at screening: * Hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure). * Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight. Exclusion Criteria: * Have Type 1 diabetes, Type 2 diabetes, or any other types of diabetes, history of ketoacidosis, or hyperosmolar state/coma * Have a self-reported change in body weight \>5 kg (11 pounds) within 90 days prior to screening. * Have family (first-degree relative) or personal history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia (MEN)2 syndrome. * Have had a history of chronic or acute pancreatitis.
Study sites by state
Arizona
- The Institute for Liver Health II dba Arizona Clinical Trials - Mesa, Chandler
- Clinical Research Institute of Arizona (CRI) - Sun City West, Sun City West
California
- John Muir Physician Network Research Center, Concord
- AMCR Institute, Escondido
- NorCal Medical Research, Inc, Greenbrae
- Velocity Clinical Research, Huntington Park, Huntington Park
- Velocity Clinical Research, Westlake, Los Angeles
- Catalina Research Institute, LLC, Montclair
- Norcal Endocrinology & Internal Medicine, San Ramon
- University Clinical Investigators, Inc., Tustin
Colorado
- University of Colorado Anschutz Medical Campus, Aurora
Florida
- New Age Medical Research Corporation, Miami
- South Broward Research, Miramar
- Renstar Medical Research, Ocala
- Jedidiah Clinical Research - Tampa - Bay Plaza, Tampa
- Clinical Site Partners, LLC dba Flourish Research, Winter Park
Georgia
- Physicians Research Associates, Lawrenceville
- East Coast Institute for Research, LLC, Macon
- Rophe Adult and Pediatric Medicine/SKYCRNG, Union City
Hawaii
- East-West Medical Research Institute, Honolulu
Idaho
- Elite Clinical Trials, Blackfoot
Kansas
- Cotton O'Neil Clinical Research Center, Topeka
- Cotton O'Neil Diabetes & Endocrinology, Topeka
Louisiana
- Pennington Biomedical Research Center, Baton Rouge
- Care Access - Lake Charles, Lake Charles
Maryland
- MedStar Health Research Institute (MedStar Physician Based Research Network), Hyattsville
- Endocrine and Metabolic Consultants, Rockville
Michigan
- Arcturus Healthcare , PLC, Troy Internal Medicine Research Division, Troy
Mississippi
- SKY Integrative Medical Center/SKYCRNG, Ridgeland
Nevada
- Las Vegas Medical Research, Las Vegas
New York
- Long Island Cardiovascular Consultants, Lake Success
- Weill Cornell Medical College, New York
Oklahoma
- Alliance for Multispecialty Research, LLC, Norman
Texas
- Texas Diabetes & Endocrinology, P.A., Austin
- Thyroid, Endocrinology, and Diabetes, Dallas
- Velocity Clinical Research, Dallas, Dallas
- Cedar Health Research, Dallas
- Juno Research, Houston
- Consano Clinical Research, LLC, Shavano Park
- Soma Clinical Trials, Wylie
Utah
- Physicians' Research Options, Draper
Virginia
- Health Research of Hampton Roads, Inc., Newport News
Washington
- Eastside Research Associates, Redmond
View the official record on ClinicalTrials.gov →
Follow this trial
Get an email when our monthly digest covers enrollment changes and results for trials like this one.