What this trial means for you
This study is active, not recruiting — it is not currently taking new participants, but its results may matter for treatments you're considering. It's studying Retatrutide, Placebo for obesity, cardiovascular diseases.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD). The study will last about 113 weeks.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Have a body mass index (BMI) ≥35.0 kilogram/square meter (kg/m²). * Have established cardiovascular (CV) disease with at least 1 of the following: * prior myocardial infarction * prior ischemic or hemorrhagic stroke, or * symptomatic peripheral arterial disease * Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight. Exclusion Criteria: * Have had acute myocardial infarction, stroke, coronary revascularization, hospitalization for unstable angina, or hospitalization due to congestive heart failure within 90 days prior to screening. * Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening. * Have a prior or planned surgical treatment of obesity. * Have a change in body weight greater than 5 kg (11 pounds) within 90 days prior to screening. * Have Type 1 diabetes. * Have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) * Have had pancreatitis.
Study sites by state
Arizona
- Central Phoenix Medical Clinic — Phoenix
California
- Valley Clinical Trials, Inc. — Covina
- Neuro-Pain Medical Center — Fresno
- Valley Research — Fresno
- Collaborative Neuroscience Research, LLC — Los Alamitos
- Velocity Clinical Research, Westlake — Los Angeles
- Valley Clinical Trials, Inc. — Northridge
- Velocity Clinical Research, Panorama City — Van Nuys
Connecticut
- Chase Medical Research, LLC — Waterbury
Florida
- Indago Research & Health Center, Inc — Hialeah
- Clinical Neuroscience Solutions, Inc. dba CNS Healthcare — Jacksonville
- Clinical Neuroscience Solutions, Inc. — Orlando
- Charter Research - Winter Park — Orlando
- Progressive Medical Research — Port Orange
Hawaii
- Pacific Diabetes & Endocrine Center — Honolulu
Idaho
- Elite Clinical Trials — Blackfoot
- Humphreys Diabetes Center — Boise
Illinois
- Northwestern University — Chicago
- Great Lakes Clinical Trials - Gurnee — Gurnee
- Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative — Springfield
Indiana
- Brengle Family Medicine — Indianapolis
Iowa
- Iowa Diabetes and Endocrinology Research Center — West Des Moines
Kansas
- Cotton O'Neil Diabetes & Endocrinology — Topeka
Massachusetts
- MedVadis Research Corporation — Waltham
Missouri
- StudyMetrix Research — City of Saint Peters
Nevada
- Las Vegas Medical Research — Las Vegas
- Palm Research Center Tenaya — Las Vegas
New Jersey
- IMA Clinical Research Warren — Warren Township
New York
- Weill Cornell Medical College — New York
- Rochester Clinical Research, LLC — Rochester
North Carolina
- Carteret Medical Group — Morehead City
Ohio
- Cleveland Clinic — Cleveland
Pennsylvania
- Altoona Center For Clinical Research — Duncansville
- UPMC Montefiore University Hospital — Pittsburgh
South Carolina
- Tribe Clinical Research, LLC — Greenville
- Trial Management Associates — Myrtle Beach
- Tribe Clinical Research - Spartanburg — Spartanburg
Texas
- Texas Diabetes & Endocrinology, P.A. — Austin
- Pinnacle Clinical Research — Austin
- South Texas Clinical Research — Corpus Christi
- Southern Endocrinology Associates — Mesquite
- Texas Diabetes & Endocrinology, P.A. — Round Rock
- Sleep Therapy Research Center — San Antonio
- Consano Clinical Research, LLC — Shavano Park
Utah
- Advanced Research Institute — Ogden
Washington
- Rainier Clinical Research Center — Renton
View the official record on ClinicalTrials.gov →
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