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HomeTrials › NCT06042153

Type 2 diabetes · Phase 4 · Active, not recruiting

DIALYSIS-TIR Study

NCT06042153 · Sponsor: University of Texas Southwestern Medical Center

What this trial means for you

This study is active, not recruiting — it is not currently taking new participants, but its results may matter for treatments you're considering. It's studying Semaglutide, Placebo for type 2 diabetes, end stage renal disease on dialysis.

Who can joinAll sexes, 18 Years and older
Healthy volunteersNo — diagnosis required
What you'd takeSemaglutide, Placebo
Study length~3.8 years overall
Planned participants43
TypeInterventional (you receive treatment)

What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.

The study, in the sponsor's words

This study will look at control of blood sugar levels in persons with type 2 diabetes mellitus currently on chronic dialysis. Researchers will compare blood sugar levels in people taking semaglutide to people taking "dummy" medicine. The treatment participants get will be decided randomly. Participants will need to inject the study medication once a week. The study will last for 1 year and a month. Participants will be asked to wear a sensor that measures blood sugar levels for a period of 10 days at five different time points during the study.

Can you join? The exact criteria

Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.

Full eligibility criteria (for you and your doctor)

Inclusion Criteria: 1. Ability to provide informed consent before any trial-related activities. Trial-related activities are any procedures that are carried out as a part of trial, including activities to determine suitability for the trial. 2. Male or female Adults (age \> 18 years at the time of signing the consent) 3. Type 2 diabetes mellitus diagnosed \> 6 months prior to screening 4. On current chronic treatment with Hemodialysis or Peritoneal dialysis for \> 6 months prior to screening 5. Current treatment with any glucose lowering pharmacotherapy, at a stable dose for at least 30 days. DPP-4 Inhibitors will be allowed at study entry and will be stopped at randomization. 6. Minimum of 80% valid data on the 10-day Continuous Glucose Monitor download 7. Time in Range 15 to 60% Exclusion Criteria: 1. BMI \< 23 kg/m2 at screening 2. Current (within the past 90 days of screening) use of any GLP-1 RA 3. Personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia type 2 4. Known or suspected hypersensitivity to GLP-1 RA (trial medication(s), excipients, or related products) 5. Pregnant, breast-feeding or the intention of becoming pregnant, or not using effective contraceptive measures 6. Active weight loss, defined as weight loss of \>5% of body weight in the past 3 months 7. Current participation in other interventional trials or last dose of any investigational product within 4 half- lives at the time of randomization 8. Any medical condition which in the judgement of the investigator precludes safe participation in the trial (includes, but not limited to active neoplasm, severe heart failure, recent cardiovascular event, severe frailty, planned cardiac or vascular surgeries on the day of screening etc) 9. If weight loss is not desired by the participant, or if the provider or investigator considers intentional weight loss to be detrimental to the health of the participant 10. Other or secondary forms of diabetes (like type 1 diabetes, pancreatogenic diabetes mellitus, MODY, LADA, drug induced, etc.) 11. Current diagnosis of gastroparesis or enteropathywhich in the opinion of investigator precludes safe treatment with GLP-1 RA. 12. Hypoglycaemia unawareness, or history of frequent or severe hypoglycaemia (in the opinion of the investigator) 13. Personal history of chronic pancreatitis, or acute pancreatitis within 180 days of screening 14. Known current uncontrolled or unstable retinopathy (by medical history)

Study sites by state

North Carolina

  • University of North Carolina — Chapel Hill

Texas

  • Davita UT Southwestern - Oak Cliff — Dallas
  • DaVita UT Southwestern - East Dallas — Dallas
  • DaVita UT Southwestern - Preston — Dallas
  • DaVita UT Southwestern - Irving — Irving

View the official record on ClinicalTrials.gov →

Verify before you act. Medical disclaimer: content on this site is for informational purposes only and is not medical advice. GLP-1 medications are prescription drugs; always consult a licensed healthcare provider about eligibility, risks, and benefits. Trial details and enrollment status change frequently — always verify on the official registry and talk to your own clinician before contacting a study site. This page was generated from registry data and is not affiliated with the study sponsor.

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