What this trial means for you
This study is recruiting now at 49 US sites. It's studying LY3305677, LY3841136, Tirzepatide, LY3549492, LY3532226, Placebo, Placebo for obesity, overweight.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Have a body mass index (BMI) * ≥30 kilogram/square meter (kg/m²), or * ≥27 kg/m² and \<30 kg/m², or with at least 1 weight-related comorbidity * Have had a stable body weight for the 3 months prior to randomization (\<5%) body weight gain and/or loss. Exclusion Criteria: * Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening. * Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma. * Have poorly controlled hypertension. * Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease. * Have any of the following cardiovascular conditions within 3 months prior to screening: * acute myocardial infarction * cerebrovascular accident (stroke) * unstable angina, or * hospitalization due to congestive heart failure. * Have a history of symptomatic gallbladder disease within the past 2 years. * Have a lifetime history of suicide attempts.
Study sites by state
Arizona
- The Institute for Liver Health II dba Arizona Clinical Trials - Mesa — Chandler · Recruiting now
- HOPE Research Institute — Phoenix · Recruiting now
- Headlands Research - Scottsdale — Scottsdale · Recruiting now
- The Institute for Liver Health II dba Arizona Liver Health-Tucson — Tucson · Recruiting now
California
- NorCal Medical Research, Inc — Greenbrae · Recruiting now
- Velocity Clinical Research, Huntington Park — Huntington Park · Recruiting now
- Peninsula Research Associates — Rolling Hills Estates · Recruiting now
- Diablo Clinical Research, Inc. — Walnut Creek · Recruiting now
Connecticut
- Stamford Therapeutics Consortium — Stamford · Recruiting now
Florida
- Northeast Research Institute (NERI) — Fleming Island · Recruiting now
- Indago Research & Health Center, Inc — Hialeah · Recruiting now
- New Horizon Research Center — Miami · Recruiting now
- Suncoast Clinical Research, Inc. — New Port Richey · Recruiting now
- Charter Research - Winter Park — Orlando · Recruiting now
- Charter Research - Lady Lake — The Villages · Recruiting now
Hawaii
- Pacific Diabetes & Endocrine Center — Honolulu · Recruiting now
Idaho
- Medical Research Partners — Ammon · Recruiting now
Illinois
- Great Lakes Clinical Trials - Ravenswood — Chicago · Recruiting now
- NorthShore University Health System — Skokie · Recruiting now
Iowa
- Iowa Diabetes and Endocrinology Research Center — West Des Moines · Recruiting now
Kansas
- Cotton O'Neil Diabetes & Endocrinology — Topeka · Recruiting now
Kentucky
- Monroe Biomedical Research - Louisville — Louisville · Recruiting now
Massachusetts
- Knownwell — Needham · Recruiting now
- Lucida Clinical Trials — New Bedford · Recruiting now
Michigan
- Headlands Research - Detroit — Southfield · Recruiting now
- Arcturus Healthcare , PLC, Troy Internal Medicine Research Division — Troy · Recruiting now
Missouri
- StudyMetrix Research — City of Saint Peters · Recruiting now
- Clinvest Headlands Llc — Springfield · Recruiting now
Nevada
- Las Vegas Medical Research — Las Vegas · Recruiting now
New York
- Dent Neurologic Institute — Amherst · Recruiting now
- Velocity Clinical Research, Syracuse — East Syracuse · Recruiting now
- North Suffolk Neurology — Port Jefferson Station · Recruiting now
- Rochester Clinical Research, LLC — Rochester · Recruiting now
North Carolina
- Medication Management — Greensboro · Recruiting now
- Monroe Biomedical Research — Monroe · Recruiting now
- Lucas Research, Inc — Morehead City · Recruiting now
- Lucas Research, Inc. — New Bern · Recruiting now
Ohio
- CTI Clinical Research Center — Cincinnati · Recruiting now
South Carolina
- Tribe Clinical Research, LLC — Greenville · Recruiting now
Tennessee
- Quality Medical Research — Nashville · Recruiting now
Texas
- IMA Clinical Research Austin — Austin · Recruiting now
- Velocity Clinical Research, Dallas — Dallas · Recruiting now
- FutureSearch Trials of Dallas — Dallas · Recruiting now
- PlanIt Research, PLLC — Houston · Recruiting now
- Endeavor Clinical Trials — San Antonio · Recruiting now
- Tekton Research - Fredericksburg Road — San Antonio · Recruiting now
- Texas Valley Clinical Research — Weslaco · Recruiting now
Virginia
- Sovah Clinical Research-River District — Danville · Recruiting now
Washington
- Central Washington Health Services Association d/b/a Confluence Health — Wenatchee · Recruiting now
View the official record on ClinicalTrials.gov →
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