What this trial means for you
This study is active, not recruiting — it is not currently taking new participants, but its results may matter for treatments you're considering. It's studying Retatrutide, Placebo for type 2 diabetes.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
The purpose of this study is to investigate the efficacy and safety of retatrutide compared with placebo in participants with Type 2 Diabetes and renal impairment, with inadequate glycemic control on basal insulin alone or a combination of basal insulin with or without metformin and/or sodium-glucose cotransporter-2 (SGLT2) inhibitor. The study will last about 14 months and may include up to 22 visits.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Have Type 2 Diabetes (T2D) * Have HbA1c ≥7.0% (53 millimoles per mole (mmol/mol)) to ≤10.5% (91 mmol/mol) * Have moderate or severe renal impairment * Have been on the following stable diabetes treatment during 90 days prior to screening * basal insulin (≥20 International Units (IU)/day) with or without * metformin and/or SGLT2 inhibitor * Are of stable weight for at least 90 days prior to screening * Have a Body Mass Index (BMI) ≥23.0 kilograms per meter squared (kg/m2) Exclusion Criteria: * Have Type 1 Diabetes (T1D) * Have a history of ketoacidosis or hyperosmolar state or coma within the last 6 months prior to screening * Have a history of severe hypoglycemia or hypoglycemia unawareness within the last 6 months prior to screening * Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema * Have a history of unstable or rapidly progressing renal disease * Have a prior or planned surgical treatment for obesity * Have New York Heart Association Functional Classification III or IV congestive heart failure * Have had acute myocardial infarction, stroke, or were hospitalized for congestive heart failure within 90 days prior to screening * Have a known clinically significant gastric emptying abnormality * Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years * Have a family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia (MEN) syndrome Type 2. * Have any lifetime history of a suicide attempt * Had chronic or acute pancreatitis * Have taken prescribed or over-the-counter medication, or alternative remedies, intended to promote body weight reduction within 90 days prior to screening
Study sites by state
Alabama
- Nephrology Consultants — Huntsville
Arizona
- Clinical Research Institute of Arizona (CRI) - Sun City West — Sun City West
California
- Kidney & Hypertension Center - Apple Valley — Apple Valley
- Hope Clinical Research, Inc. — Canoga Park
- Neighborhood Healthcare Institute of Health — Escondido
- EndoTrials Center for Clinical Research — La Mesa
- UCLA South Bay Endocrinology — Torrance
Florida
- Northeast Research Institute (NERI) — Fleming Island
- Encore Medical Research - Weston — Weston
Georgia
- Orita Clinical Research — Decatur
Idaho
- CARE Institute — Idaho Falls
Kansas
- Cotton O'Neil Diabetes & Endocrinology — Topeka
Montana
- Billings Clinic — Billings
Nevada
- Excel Clinical Research, LLC — Las Vegas
New York
- Albany Medical College, Division of Community Endocrinology — Albany
- NYC Research INC — Long Island City
- Research Foundation of SUNY - University of Buffalo — Williamsville
North Carolina
- University of North Carolina Medical Center — Chapel Hill
Oklahoma
- Central States Research — Tulsa
Pennsylvania
- Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair — Pittsburgh
Tennessee
- AM Diabetes & Endocrinology Center — Bartlett
Texas
- Velocity Clinical Research, Dallas — Dallas
- Prime Revival Research Institute, LLC — Flower Mound
- Juno Research — Houston
- PlanIt Research, PLLC — Houston
- Southern Endocrinology Associates — Mesquite
- Texas Valley Clinical Research — Weslaco
Utah
- Diabetes & Endocrine Treatment Specialists — Sandy City
View the official record on ClinicalTrials.gov →
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