What this trial means for you
This study is active, not recruiting — it is not currently taking new participants, but its results may matter for treatments you're considering. It's studying Semaglutide for obesity.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
The study is testing how well semaglutide can help adolescents with excess body weight to lose weight and to maintain weight loss. All participants in the study will receive semaglutide as a weekly injection. The study medicine is injected with a thin needle in the stomach, thighs or upper arms. All participants will get semaglutide treatment for a minimum of 3 years.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion criteria: * Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study: 1. The parent(s) or legally acceptable representative (LAR) of the participant must sign and date the Informed Consent Form, according to local requirements 2. The participant must sign and date the Child Assent Form or provide oral assent, according to local requirements * Age 12 to less than 15 years at the time of signing the informed consent * BMI greater than or equal to 95th percentile at screening * Body weight greater than 60 kg at screening Exclusion criteria: * Prepubertal status (Tanner stage 1) * Treatment with any medication prescribed for the indication of obesity or weight management within 90 days before screening * Previous or planned (during the study period) obesity treatment with surgery or a weight loss device. However, the following are allowed: 1. Liposuction and/or abdominoplasty, if performed more than 1 year prior to screening 2. Adjustable gastric banding, if the band has been removed more than 1 year prior to screening 3. Intragastric balloon, if the balloon has been removed more than 1 year prior to screening 4. Duodenal-jejunal bypass liner (e.g., Endobarrier), if the sleeve has been removed more than 1 year prior to screening * Endocrine, hypothalamic, or syndromic obesity * History of type 1 or type 2 diabetes mellitus
Study sites by state
California
- Neighborhood Healthcare — Escondido
Florida
- Clinical Neuroscience Solution — Orlando
- TMH Physician Partners Endo — Tallahassee
Georgia
- Children's Healthcare Atlanta — Atlanta
- Columbus Research Foundation — Columbus
- Eastside Bariatric and Gen Surg — Snellville
Idaho
- Solaris Clinical Research — Meridian
Illinois
- Synexus Clinical Research US Inc.-Chicago — Chicago
Indiana
- Indiana University Hospital — Indianapolis
Iowa
- University Of Iowa Hospitals and Clinics — Iowa City
Louisiana
- Pennington Biom Res Ctr — Baton Rouge
Maryland
- Barry J. Reiner, MD LLC — Baltimore
Minnesota
- University of Minnesota — Minneapolis
Mississippi
- Mississippi CTR for ADV MED — Madison
New York
- UBMD Peds-Div of Endo/Diabetes — Buffalo
North Carolina
- WakeMed Childn Endo-Dbt_Raleig — Raleigh
North Dakota
- Valley Weight Loss Clinic — Fargo
Ohio
- Centricity Research - Ohio — Columbus
- PriMed Clinical Research — Dayton
Pennsylvania
- UPMC Child Hosp-Pittsburgh — Pittsburgh
South Carolina
- Coastal Carolina Research Ctr — North Charleston
Tennessee
- Clinical Neuroscience Solutions — Memphis
Texas
- Texas Diabetes Institute — San Antonio
- Clinical Trials of Texas Inc — San Antonio
Virginia
- Health Res of Hampton Roads — Newport News
- Virginia Commonwealth Univ — Richmond
View the official record on ClinicalTrials.gov →
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