What this trial means for you
This study is active, not recruiting — it is not currently taking new participants, but its results may matter for treatments you're considering. It's studying Retatrutide, Placebo for obesity.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
This is a study of retatrutide in participants with obesity. The main purpose is to learn more about how retatrutide maintains body weight loss. The study will have two treatment phases: an 80 week lead-in phase in which all participants will take retatrutide dose 1 and a 36 week randomized, double-blinded phase in which participants will either take retatrutide dose 1, retatrutide dose 2, or switch to placebo. Participation in the study will last around 125 weeks.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Have obesity and a history of at least one self-reported unsuccessful dietary effort to reduce body weight Exclusion Criteria: * Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days before screening * Have a prior or planned surgical treatment for obesity * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity * Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes * Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) * Have had within the past 90 days before screening: * acute myocardial infarction * cerebrovascular accident (stroke) * hospitalization for unstable angina, or * hospitalization due to congestive heart failure * Have New York Heart Association Functional Classification Class IV congestive heart failure * Have a history of chronic or acute pancreatitis * Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening
Study sites by state
California
- Southern California Clinical Research — Santa Ana
Colorado
- University of Colorado Anschutz Medical Campus — Aurora
Connecticut
- CMR of Greater New Haven, LLC — Hamden
Florida
- ALL Medical Research, LLC — Cooper City
- Florida International Medical Research — Coral Gables
- Renstar Medical Research — Ocala
- Charter Research - Winter Park — Orlando
- Metabolic Research Institute, Inc. — West Palm Beach
Georgia
- Kubost Clinical Research - Marietta — Marietta
- North Georgia Clinical Research — Woodstock
Hawaii
- Pacific Diabetes & Endocrine Center — Honolulu
Illinois
- Alliance for Multispecialty Research, LLC — Oak Brook
- Springfield Clinic Main Campus — Springfield
Kentucky
- Alliance for Multispecialty Research, LLC — Lexington
- L-MARC Research Center — Louisville
Louisiana
- Pennington Biomedical Research Center — Baton Rouge
- Care Access - Lake Charles (Bayou Pines) — Lake Charles
Massachusetts
- Massachusetts General Hospital — Boston
Missouri
- Alliance for Multispecialty Research, LLC — Kansas City
Nevada
- Vector Clinical Trials — Las Vegas
New York
- Dent Neurosciences Research Center, Inc — Amherst
North Carolina
- Carteret Medical Group — Morehead City
- Care Access - Raleigh — Raleigh
Oklahoma
- Tekton Research, LLC. — Moore
Pennsylvania
- Altoona Center For Clinical Research — Duncansville
South Dakota
- Care Access - Rapid City — Rapid City
Tennessee
- Alliance for Multispecialty Research, LLC — Knoxville
Texas
- Care Access - Houston — Houston
- Southern Endocrinology Associates — Mesquite
- Sleep Therapy Research Center — San Antonio
Virginia
- National Clinical Research, Inc — Richmond
Washington
- Northwest Clinical Research Center — Bellevue
- Central Washington Health Services Association d/b/a Confluence Health — Wenatchee
View the official record on ClinicalTrials.gov →
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