What this trial means for you
This study is active, not recruiting — it is not currently taking new participants, but its results may matter for treatments you're considering. It's studying Tirzepatide, Placebo for type 1 diabetes, obesity, overweight.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
The main purpose of this study is to find out how well and how safely tirzepatide works long-term in adults who have type 1 diabetes and obesity or overweight. Participation in the study will last about 20 months.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Have type 1 diabetes and on insulin treatment for at least one year prior to screening * Have an HbA1c value of 7.0% to 10.5% inclusive, at screening * Have a body mass index (BMI) of ≥25 kilograms per square meter (kg/m2) at screening * Are of stable weight for at least 90 days prior to screening and agree to not start an intensive diet or exercise program during the study Exclusion Criteria: * Have experienced two or more events requiring hospitalization due to poor glucose control (hyperglycemia or (diabetic ketoacidosis (DKA)) during the period of 180 days prior to screening and until randomization. * Have experienced one or more events of severe hypoglycemia during the period of 90 days prior to screening and until randomization. * Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema * Have had chronic or acute pancreatitis * Have used any weight loss drugs or alternative remedies, including herbal or nutritional supplements, within 90 days prior to screening
Study sites by state
California
- Kaiser Permanente Bonita Medical Offices — Bonita
- AMCR Institute — Escondido
- Mary & Dick Allen Diabetes Center — Newport Beach
- University Clinical Investigators, Inc. — Tustin
Colorado
- University of Colorado Anschutz Medical Campus — Aurora
Florida
- Metabolic Research Institute, Inc. — West Palm Beach
Iowa
- Iowa Diabetes and Endocrinology Research Center — West Des Moines
Minnesota
- HealthPartners Institute dba International Diabetes Center — Minneapolis
Missouri
- Clinical Research Professionals — Chesterfield
- Clinvest Headlands Llc — Springfield
Nevada
- Las Vegas Endocrinology — Henderson
North Carolina
- University of North Carolina Medical Center — Chapel Hill
Texas
- Velocity Clinical Research, Dallas — Dallas
- Juno Research — Houston
- Southern Endocrinology Associates — Mesquite
- Texas Diabetes & Endocrinology, P.A. — Round Rock
- San Antonio Clinical Trials — San Antonio
- Texas Valley Clinical Research — Weslaco
View the official record on ClinicalTrials.gov →
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