What this trial means for you
This study is active, not recruiting. It is not currently taking new participants, but its results may matter for treatments you're considering. It's studying Retatrutide, Placebo for obesity, overweight, chronic low back pain (clbp).
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study, ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
The main purpose of this study is to evaluate the efficacy and safety of retatrutide in relieving chronic low back pain in participants who have obesity or overweight. Participation in the study will last about 80 weeks.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry. Bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Have a history of axial-predominant low back pain * Have pain that is restricted to the low back or with a referral pattern limited to the proximal legs * Have a body mass index (BMI) ≥27 kilograms per square meter (kg/m2) at screening * Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight Exclusion Criteria: * Have a non-axial origin low back pain * Have had botulinum or steroid injections to the spine within 1 year of screening * Have had trigger point injection to the spine within 6 months of screening * Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days prior to screening * Have been taking drugs to promote body weight reduction, including over-the-counter medications, within 90 days prior to screening * Have a prior or planned surgical treatment for obesity * Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes
Study sites by state
Arizona
- MD First Research - Chandler, Chandler
- Tucson Orthopaedic Institute - North Wyatt Drive, Tucson
California
- Ark Clinical Research - Fountain Valley, Fountain Valley
- St Joseph Heritage Healthcare, Fullerton
- Clinical Research Institute, Los Angeles
- Artemis Institute for Clinical Research, San Diego
Colorado
- Alpine Clinical Research Center, Boulder
Florida
- K2 Medical Research - Daytona Beach, Daytona Beach
- Flourish Research - Miami, LLC, Miami
- IMA Clinical Research St. Petersburg, St. Petersburg
- Care Access - Tampa, Tampa
- Charter Research - Lady Lake, The Villages
- Conquest Research, Winter Park
Kansas
- Cotton O'Neil Clinical Research Center, Topeka
Louisiana
- Care Access - Lake Charles (Bayou Pines), Lake Charles
Massachusetts
- MedVadis Research Corporation, Waltham
Michigan
- Great Lakes Research Group, Inc., Bay City
Missouri
- Clinvest Headlands Llc, Springfield
North Carolina
- Center for Clinical Research, Winston-Salem
Pennsylvania
- Altoona Center For Clinical Research, Duncansville
Tennessee
- New Phase Research and Development, Knoxville
Texas
- FutureSearch Trials of Neurology, Austin
- Mercy Family Clinic, Dallas
- Houston Research Institute, Houston
Virginia
- Sovah Clinical Research-River District, Danville
View the official record on ClinicalTrials.gov →
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