What this trial means for you
This study is active, not recruiting — it is not currently taking new participants, but its results may matter for treatments you're considering. It's studying RO7795081, Semaglutide, Placebo for type 2 diabetes mellitus.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
This multicenter, randomized, double-blind, placebo- and open-label active comparator-controlled, parallel-group, dose-range-finding, Phase II study aims to evaluate the efficacy, tolerability, and safety of RO7795081 for glycemic control in adult participants with Type 2 diabetes mellitus (T2D).
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Have a diagnosis of Type 2 diabetes mellitus (T2D) for at least 6 months before screening * Have an HbA1c ≥7% and ≤10.5% at screening * Management of T2D with diet and exercise alone or with either a stable dose of metformin or/and sodium-glucose cotransporter-2 (SGLT-2) inhibitors * Body mass index (BMI) ≥23.0 kg/m\^2 at screening * A stable body weight within 3 months prior to screening (maximum 5% self-reported body weight gain and/or loss) Exclusion Criteria: * Have Type 1 diabetes (T1D), history of ketosis or hyperosmolar state/coma, or any other types of diabetes except T2D * Have had 1 or more episodes of Level 3 hypoglycemia or has hypoglycemia unawareness within the 6 months prior to screening * History or presence of proliferative diabetic retinopathy, diabetic macular edema, or non-proliferative diabetic retinopathy that requires acute treatment * Evidence of clinically significant/active nephropathy or neuropathy (including resting tachycardia, orthostatic hypotension, and diabetic diarrhea) * Current treatment or treatment within 3 months of screening with any other anti-hyperglycemic medication except metformin or SGLT-2 inhibitors * Have obesity induced by other endocrinologic disorders (e.g., Cushing's syndrome) or diagnosed monogenetic or syndromic forms of obesity (e.g., melanocortin-4 receptor deficiency or Prader-Willi Syndrome) * Have a known, clinically significant gastric emptying abnormality * Have poorly controlled hypertension at screening, untreated renal artery stenosis, or evidence of labile blood pressure including symptomatic postural hypotension * Have any of the following cardiovascular conditions within 3 months prior to screening: Acute myocardial infarction; Cerebrovascular accident (stroke)/transient ischemic attack; Unstable angina; Hospitalization due to congestive heart failure
Study sites by state
Arizona
- Arizona Liver Health - Tucson — Tucson
California
- Orange County Research Center — Lake Forest
- Prospective Research Innovations Inc. — Rancho Cucamonga
- Encompass Clinical Research — Spring Valley
Connecticut
- Chase Medical Research — Waterbury
District of Columbia
- Emerson Clinical Research Institute — Washington D.C.
Florida
- K2 Medical Research South Orlando, LLC — Clermont
- Center for Diabetes, Obesity and Metabolism Inc — Pembroke Pines
Georgia
- Rophe Adult and Pediatric Medicine/SKYCRNG — Union City
Illinois
- Accellacare of Duly Health and Care — Oak Lawn
Montana
- Mercury Street Medical Group, PLLC — Butte
New York
- Neurobehavioral Research, Inc. — Cedarhurst
North Carolina
- Accellacare of Piedmont Healthcare — Statesville
- Accellacare of Wilmington, LLC — Wilmington
Ohio
- NexGen Research — Lima
Pennsylvania
- Tristar Clinical Investigations — Philadelphia
Tennessee
- Alliance for Multispecialty Research. LLC — Knoxville
- Clinical Research Associates — Nashville
Texas
- Texas Diabetes & Endocrinology, P.A. — Austin
- Apex Mobile Clinical Research — Bellaire
- Velocity Clinical Research — Dallas
- Velocity Clinical Research (Impact Research Institute) — Waco
Utah
- Chrysalis Clinical Research — St. George
Virginia
- Manassas Clinical Research Center — Manassas
View the official record on ClinicalTrials.gov →
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