What this trial means for you
This study is recruiting now at 26 US sites. It's studying Orforglipron, Placebo for osteoarthritis.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 74 weeks.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening * Have tried at least once to lose weight through diet but were unsuccessful * Have osteoarthritis of the knee and at least one of the following conditions: * Be over 50 years old * Have morning knee stiffness that lasts about 30 minutes * Have a crackling or grinding sound or feeling in the knee Exclusion Criteria: * Have gained or lost more than 11 pounds within 90 days prior to screening * Have had a surgery for obesity or plan to have one in the next 18 months * Have an active knee infection * Have type 1 diabetes, type 2 diabetes, or any other type of diabetes * Have had a recent heart condition or New York Heart Association Functional Classification Class IV congestive heart failure * Have used any glucagon-like peptide-1 (GLP-1) receptor agonist medication within 180 days of screening
Study sites by state
Arizona
- Arizona Research Center — Phoenix · Recruiting now
- AMR Clinical — Tempe · Recruiting now
California
- Care Access - Huntington Beach — Huntington Beach · Recruiting now
- Care Access - Thousand Oaks — Thousand Oaks · Recruiting now
Colorado
- Legacy Clinical Trials — Colorado Springs · Recruiting now
Connecticut
- Chase Medical Research, LLC — Waterbury · Recruiting now
Georgia
- Care Access - Decatur — Decatur · Recruiting now
- North Georgia Clinical Research — Woodstock · Recruiting now
Illinois
- Northwestern University — Chicago · Recruiting now
Kansas
- AMR Clinical — Newton · Recruiting now
Massachusetts
- MedVadis Research Corporation — Waltham · Recruiting now
Missouri
- StudyMetrix Research — City of Saint Peters · Recruiting now
- AMR Clinical — Kansas City · Recruiting now
New Jersey
- Cardio Metabolic Institute — Somerset · Recruiting now
North Carolina
- Carolina Research Center — Shelby · Recruiting now
Pennsylvania
- University Orthopedics Center — Altoona · Recruiting now
South Dakota
- Care Access - Rapid City — Rapid City · Recruiting now
Tennessee
- AMR Clinical — Knoxville · Recruiting now
Texas
- Mercy Family Clinic — Dallas · Recruiting now
- Juno Research — Houston · Recruiting now
- Biopharma Informatic, LLC — Houston · Recruiting now
- Activian Clinical Research — Kingwood · Recruiting now
- Advanced Rheumatology of Houston - Woodlands — The Woodlands · Recruiting now
Virginia
- Charlottesville Medical Research — Charlottesville · Recruiting now
- Gershon Pain Specialists — Virginia Beach · Recruiting now
Washington
- Northwest Clinical Research Center — Bellevue · Recruiting now
View the official record on ClinicalTrials.gov →
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