What this trial means for you
This study is active, not recruiting. It is not currently taking new participants, but its results may matter for treatments you're considering. It's studying aleniglipron or placebo for obesity, overweight, or chronic weight management.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study, ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
This is a randomized, double-blind, placebo-controlled study evaluating the effects of aleniglipron on body composition in participants living with obesity. Participants will be randomized to aleniglipron or placebo in a ratio of 5:1. Participants will receive multiple ascending QD doses of aleniglipron or placebo in titration steps of 4 weeks duration for a total of 40 weeks of treatment.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry. Bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Signed informed consent * Participants age ≥18 years and \<80 years, with BMI ≥30 kg/m2 * Screening HbA1c \<6.5 % Exclusion Criteria: * Previous documented diagnosis of diabetes mellitus * Self-reported change in body weight \>5% within 3 months before Screening * Have a body weight, height, and/or width that prohibits the ability to obtain accurate measurements according to the DXA study specific manual that allows hemi-scan * Have a prior or planned surgical treatment for obesity (excluding liposuction or abdominoplasty, if performed \>1 year prior to screening) * Have obesity induced by other endocrine disorders (such as Cushing's syndrome, Prader-Willi syndrome, or melanocortin 4 receptor deficiency)
Study sites by state
Arizona
- Research Site, Phoenix
Illinois
- Research Site, Chicago
Minnesota
- Research Site, Richfield
Missouri
- Research Site, City of Saint Peters
New York
- Research Site, Rochester
North Carolina
- Research Site, Wilmington
Oklahoma
- Research Site, Norman
South Carolina
- Research Site, Moncks Corner
- Research Site, North Charleston
Texas
- Research Site, Austin
- Research Site, San Antonio
View the official record on ClinicalTrials.gov →
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