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HomeTrials › NCT07220759

Obesity & weight · Phase 3 · Active, not recruiting

Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide

NCT07220759 · Sponsor: Novo Nordisk A/S

What this trial means for you

This study is active, not recruiting — it is not currently taking new participants, but its results may matter for treatments you're considering. It's studying Cagrilintide, Placebo (matched to Cagrilintide) for overweight, obesity, type 2 diabetes.

Who can joinAll sexes, 18 Years and older
Healthy volunteersNo — diagnosis required
What you'd takeCagrilintide, Placebo (matched to Cagrilintide)
Study length~18 months overall
Planned participants330
TypeInterventional (you receive treatment)

What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.

The study, in the sponsor's words

This study will look at how much cagrilintide helps people with overweight or obesity and type 2 diabetes lower their body weight. Cagrilintide is a new investigational medicine. Doctors may not yet prescribe cagrilintide. Participant will either get cagrilintide or placebo. Which treatment participant get is decided by chance. Participants are two times more likely to get cagrilintide than placebo. Like all medicines, the study medicine may have side effects. For each participant, the study will last for about 1 year and 6 months.

Can you join? The exact criteria

Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.

Full eligibility criteria (for you and your doctor)

Key Inclusion Criteria: * Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study. * Female or male (sex at birth). * Age 18 years or above at the time of signing the informed consent. * History of at least one self-reported unsuccessful dietary effort to lose body weight.(a\*) * Body mass index (BMI) \>= 27.0 kilogram per square meter (kg/m\^2).(a\*) * Diagnosed with type 2 diabetes \>= 180 days before screening. * Treatment with either lifestyle intervention(a\*), or: * Stable treatment (same drug(s), dose and dosing frequency) for at least 90 days before screening with 1-3 marketed oral antidiabetic drugs (metformin, α-glucosidase inhibitors (AGI), glinides, sodium-glucose cotransporter 2 inhibitor (SGLT2i), thiazolidinediones, Dipeptidyl peptidase-4 inhibitor (DPP-4i) or sulphonylureas (SU) as a single agent or in combination according to local practice.(a\*) * For up to 30% of participants the following concomitant medication is allowed: * Treatment for any indication with a stable dose of glucagon-like peptide-1 (GLP-1) containing medication, stable for at least 1 year before screening (a\*) and/or * Treatment with basal insulin minimum (0.25 units per kilogram per day (U/kg/day) or 20 units per day \[U/day\]) stable for at least 90 days before screening.(a\*) Key Exclusion Criteria: * Treatment, or intention to initiate treatment, with any medication prescribed for the indication of weight management within 180 days before screening.(a\*) * Treatment with glucagon-like peptide-1 (GLP-1) receptor agonist (RA) or GLP-1 containing medication within 180 days before screening, apart from those randomized according to inclusion criteria 7bi.(a\*) * Previous dosing of marketed or non-marketed amylin-based compounds.(a\*) (a\*) - As declared by the participant, reported in the medical records or at the investigator's discretion.

Study sites by state

Alabama

  • Univ of Alabama_Birmingham — Birmingham
  • Chambliss Clinical Trials, LLC — Montgomery

Arizona

  • Elite Clinical Network - Tucson — Tucson

California

  • Scripps Whittier Diabetes Inst — La Jolla
  • Clinical Trials Research — Lincoln
  • Pacific Clinical Studies — Los Alamitos

Florida

  • Walgreens - Store 4442 — Kissimmee
  • Optimal Research Sites — Orange City
  • Center for Diab,Obes & Metab — Pembroke Pines
  • Palm Beach Research Center — West Palm Beach

Hawaii

  • East West Med Res Inst — Honolulu

Indiana

  • MediSphere Medical RC — Evansville

Nevada

  • Walgreens - Store 3915 — Las Vegas

New York

  • Chear Center LLC — The Bronx

North Carolina

  • Centricity Res New Bern Multispeciality — New Bern
  • Accellacare — Wilmington

South Carolina

  • Spartanburg Medical Research — Spartanburg

Tennessee

  • Holston Medical Group_Bristol — Bristol

Texas

  • Velocity Clinical Res-Dallas — Dallas

Virginia

  • TPMG Clinical Research — Newport News
  • National Clin Res Inc. — Richmond

View the official record on ClinicalTrials.gov →

Verify before you act. Medical disclaimer: content on this site is for informational purposes only and is not medical advice. GLP-1 medications are prescription drugs; always consult a licensed healthcare provider about eligibility, risks, and benefits. Trial details and enrollment status change frequently — always verify on the official registry and talk to your own clinician before contacting a study site. This page was generated from registry data and is not affiliated with the study sponsor.

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