What this trial means for you
This study is active, not recruiting — it is not currently taking new participants, but its results may matter for treatments you're considering. It's studying Cagrilintide, Placebo (matched to Cagrilintide) for overweight, obesity, type 2 diabetes.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
This study will look at how much cagrilintide helps people with overweight or obesity and type 2 diabetes lower their body weight. Cagrilintide is a new investigational medicine. Doctors may not yet prescribe cagrilintide. Participant will either get cagrilintide or placebo. Which treatment participant get is decided by chance. Participants are two times more likely to get cagrilintide than placebo. Like all medicines, the study medicine may have side effects. For each participant, the study will last for about 1 year and 6 months.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Key Inclusion Criteria: * Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study. * Female or male (sex at birth). * Age 18 years or above at the time of signing the informed consent. * History of at least one self-reported unsuccessful dietary effort to lose body weight.(a\*) * Body mass index (BMI) \>= 27.0 kilogram per square meter (kg/m\^2).(a\*) * Diagnosed with type 2 diabetes \>= 180 days before screening. * Treatment with either lifestyle intervention(a\*), or: * Stable treatment (same drug(s), dose and dosing frequency) for at least 90 days before screening with 1-3 marketed oral antidiabetic drugs (metformin, α-glucosidase inhibitors (AGI), glinides, sodium-glucose cotransporter 2 inhibitor (SGLT2i), thiazolidinediones, Dipeptidyl peptidase-4 inhibitor (DPP-4i) or sulphonylureas (SU) as a single agent or in combination according to local practice.(a\*) * For up to 30% of participants the following concomitant medication is allowed: * Treatment for any indication with a stable dose of glucagon-like peptide-1 (GLP-1) containing medication, stable for at least 1 year before screening (a\*) and/or * Treatment with basal insulin minimum (0.25 units per kilogram per day (U/kg/day) or 20 units per day \[U/day\]) stable for at least 90 days before screening.(a\*) Key Exclusion Criteria: * Treatment, or intention to initiate treatment, with any medication prescribed for the indication of weight management within 180 days before screening.(a\*) * Treatment with glucagon-like peptide-1 (GLP-1) receptor agonist (RA) or GLP-1 containing medication within 180 days before screening, apart from those randomized according to inclusion criteria 7bi.(a\*) * Previous dosing of marketed or non-marketed amylin-based compounds.(a\*) (a\*) - As declared by the participant, reported in the medical records or at the investigator's discretion.
Study sites by state
Alabama
- Univ of Alabama_Birmingham — Birmingham
- Chambliss Clinical Trials, LLC — Montgomery
Arizona
- Elite Clinical Network - Tucson — Tucson
California
- Scripps Whittier Diabetes Inst — La Jolla
- Clinical Trials Research — Lincoln
- Pacific Clinical Studies — Los Alamitos
Florida
- Walgreens - Store 4442 — Kissimmee
- Optimal Research Sites — Orange City
- Center for Diab,Obes & Metab — Pembroke Pines
- Palm Beach Research Center — West Palm Beach
Hawaii
- East West Med Res Inst — Honolulu
Indiana
- MediSphere Medical RC — Evansville
Nevada
- Walgreens - Store 3915 — Las Vegas
New York
- Chear Center LLC — The Bronx
North Carolina
- Centricity Res New Bern Multispeciality — New Bern
- Accellacare — Wilmington
South Carolina
- Spartanburg Medical Research — Spartanburg
Tennessee
- Holston Medical Group_Bristol — Bristol
Texas
- Velocity Clinical Res-Dallas — Dallas
Virginia
- TPMG Clinical Research — Newport News
- National Clin Res Inc. — Richmond
View the official record on ClinicalTrials.gov →
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