What this trial means for you
This study is opening soon at 1 US site. It's studying Tirzepatide for obesity & overweight.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study — ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
This is clinical trials is to evaluate the effect of exercise with weight loss medication compared to weight loss alone. The study will enroll 24 adults from 30-65 years old with overweight or obesity. The main questions it will answer includes: * Does exercise combined with weight loss medication reduce body weight and body fat more than weight loss medication alone * Does exercise combined with weight loss medication improve other risk factors more such as the sugar in the blood, cholesterol, fitness, and quality of life Participants will: * Take a weight loss medication (tirzepatide) monthly under the supervision of their primary care physician * (Exercise group only) Will perform exercise \~3 times a week at the University of Virginia). Walking on a treadmill and resistance training * Visit the study site at the beginning of the study and after the study to evaluate weight, body fat, and other health measures
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry — bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Men and women 30-65 years of age, postmenopausal women included * 27-29.9 with an additional CVD risk factor or 30-40 kg/m2 * For overweight adults only: additional cardiometabolic risk factor (diagnosed dyslipidemia, hypertension) * Willingness and adequate health to go on weight loss medication * The capability and willingness to provide written informed consent * Approval of their primary care provider to go on weight loss medication Exclusion Criteria: * Including but not limited to serious arrhythmias * Cardiomyopathy * Congestive heart failure * Stroke or transient ischemic attacks * Peripheral vascular disease * Previous history of myocardial infarction or stroke * Previous diagnosis or taking medication for type 1 or 2 diabetes, fasting glucose \>125 mg/dL or HbA1C ≥6.5% * Systolic blood pressure \>160 mmHg and diastolic blood pressure \>100 mmHg. * Hospitalization for mental illness within the past 5 years or currently undergoing treatment for severe mental illness * Conditions that can be aggravated or are contraindicated by exercise training * Plans to be out of town more than 3 weeks in the next 4 months. * Currently pregnant or plans to become pregnant * Currently in a diet or exercise program * Non-compliance during screening or extreme difficulty in obtaining baseline blood samples * Enrolled in a different exercise program * Previous weight loss surgery * Use of weight loss medication within the last year * hypo/hyper thyroid (medicated or unmedicated)
Study sites by state
Virginia
- University of Virginia — Charlottesville
View the official record on ClinicalTrials.gov →
Follow this trial
Get an email when our monthly digest covers enrollment changes and results for trials like this one.
Newsletter signup launches soon. (Site owner: set PUBLIC_BUTTONDOWN_USERNAME in
.env to activate this form.)