What this trial means for you
This study is opening soon at 74 US sites. It's studying aleniglipron, aleniglipron, aleniglipron, Placebo for obesity, overweight, chronic weight management.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study, ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
This is randomized, double-blind, placebo-controlled study of the long-term efficacy, safety, and tolerability of multiple doses of aleniglipron in participants living with overweight or obesity and T2DM. Participants will be randomized to aleniglipron or placebo for a total of 76 weeks of treatment.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry. Bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Signed Informed Consent * Have a BMI ≥27.0 kg/m2 at Screening * Have a diagnosis of T2DM according to the WHO classification or other locally applicable standards, with HbA1c ≥6.5% (≥53 mmol/mol) to ≤10% (86 mmol/mol) at Screening Exclusion Criteria: * Have type 1 diabetes, history of ketoacidosis or hyperosmolar state/coma, or any other types of diabetes except T2DM. * Have had 1 or more episode of severe hypoglycemia and/or 1 or more episode of hypoglycemia unawareness within 180 days prior to Screening. * Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema * Self-reported change in body weight \>5 kg (11 pounds) within 3 months before Screening. * Have prior or planned surgical or non-surgical treatment for obesity.
Study sites by state
Alabama
- ACCOMPLISH-2 Research Site, Birmingham
Arizona
- ACCOMPLISH-2 Research Site, Chandler
- ACCOMPLISH-2 Research Site, Phoenix
- ACCOMPLISH-2 Research Site, Sun City West
- ACCOMPLISH-2 Research Site, Tucson
Arkansas
- ACCOMPLISH-2 Research Site, Little Rock
California
- ACCOMPLISH-2 Research Site, Escondido
- ACCOMPLISH-2 Research Site, Fountain Valley
- ACCOMPLISH-2 Research Site, Lake Forest
- ACCOMPLISH-2 Research Site, Rolling Hills Estates
- ACCOMPLISH-2 Research Site, San Diego
- ACCOMPLISH-2 Research Site, San Diego
- ACCOMPLISH-2 Research Site, Tustin
Connecticut
- ACCOMPLISH-2 Research Site, Waterbury
Florida
- ACCOMPLISH-2 Research Site, Clearwater
- ACCOMPLISH-2 Research Site, Fort Myers
- ACCOMPLISH-2 Research Site, Jacksonville
- ACCOMPLISH-2 Research Site, Leesburg
- ACCOMPLISH-2 Research Site, Miami
- ACCOMPLISH-2 Research Site, Ocala
- ACCOMPLISH-2 Research Site, Ocoee
- ACCOMPLISH-2 Research Site, Pembroke Pines
Georgia
- ACCOMPLISH-2 Research Site, Atlanta
- ACCOMPLISH-2 Research Site, Columbus
- ACCOMPLISH-2 Research Site, Lawrenceville
- ACCOMPLISH-2 Research Site, Union City
- ACCOMPLISH-2 Research Site, Woodstock
Idaho
- ACCOMPLISH-2 Research Site, Meridian
Iowa
- ACCOMPLISH-2 Research Site, Des Moines
- ACCOMPLISH-2 Research Site, Iowa City
Kansas
- ACCOMPLISH-2 Research Site, Wichita
Maryland
- ACCOMPLISH-2 Research Site, Silver Spring
Massachusetts
- ACCOMPLISH-2 Research Site, Methuen
Minnesota
- ACCOMPLISH-2 Research Site, Mankato
- ACCOMPLISH-2 Research Site, Minneapolis
Mississippi
- ACCOMPLISH-2 Research Site, Gulfport
- ACCOMPLISH-2 Research Site, Ridgeland
Missouri
- ACCOMPLISH-2 Research Site, Chesterfield
- ACCOMPLISH-2 Research Site, City of Saint Peters
- ACCOMPLISH-2 Research Site, Hazelwood
- ACCOMPLISH-2 Research Site, Springfield
- ACCOMPLISH-2 Research Site, St Louis
Montana
- ACCOMPLISH-2 Research Site, Missoula
Nebraska
- ACCOMPLISH-2 Research Site, Omaha
Nevada
- ACCOMPLISH-2 Research Site, Las Vegas
New York
- ACCOMPLISH-2 Research Site, Albany
- ACCOMPLISH-2 Research Site, Albany
- ACCOMPLISH-2 Research Site, Brooklyn
- ACCOMPLISH-2 Research Site, The Bronx
North Carolina
- ACCOMPLISH-2 Research Site, Charlotte
- ACCOMPLISH-2 Research Site, Durham
- ACCOMPLISH-2 Research Site, Fayetteville
- ACCOMPLISH-2 Research Site, Morehead City
- ACCOMPLISH-2 Research Site, Winston-Salem
Ohio
- ACCOMPLISH-2 Research Site, Columbus
Oklahoma
- ACCOMPLISH-2 Research Site, Moore
- ACCOMPLISH-2 Research Site, Tulsa
- ACCOMPLISH-2 Research Site, Yukon
Oregon
- ACCOMPLISH-2 Research Site, Portland
Pennsylvania
- ACCOMPLISH-2 Research Site, Philadelphia
South Carolina
- ACCOMPLISH-2 Research Site, Greer
Tennessee
- ACCOMPLISH-2 Research Site, Nashville
Texas
- ACCOMPLISH-2 Research Site, Austin
- ACCOMPLISH-2 Research Site, Farmers Branch
- ACCOMPLISH-2 Research Site, Houston
- ACCOMPLISH-2 Research Site, Houston
- ACCOMPLISH-2 Research Site, San Antonio
- ACCOMPLISH-2 Research Site, San Antonio
- ACCOMPLISH-2 Research Site, Wylie
Utah
- ACCOMPLISH-2 Research Site, Salt Lake City
Virginia
- ACCOMPLISH-2 Research Site, Burke
- ACCOMPLISH-2 Research Site, Manassas
- ACCOMPLISH-2 Research Site, Suffolk
Washington
- ACCOMPLISH-2 Research Site, Renton
View the official record on ClinicalTrials.gov →
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