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HomeTrials › NCT07662213

Type 2 diabetes · Phase 3 · Recruiting now

A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus

NCT07662213 · Sponsor: AstraZeneca

What this trial means for you

This study is recruiting now at 63 US sites. It's studying Elecoglipron, Semaglutide for type 2 diabetes mellitus.

Who can joinAll sexes, 18 Years and older
Healthy volunteersNo, diagnosis required
What you'd takeElecoglipron, Semaglutide
Study length~23 months overall
Planned participants1,200
TypeInterventional (you receive treatment)

What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study, ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.

The study, in the sponsor's words

The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with oral semaglutide in adults with T2DM and increased cardiovascular risk that is inadequately managed alone or on stable treatment with other background glucose-lowering medication(s).

Can you join? The exact criteria

Below is the verbatim eligibility text from the registry. Bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.

Full eligibility criteria (for you and your doctor)

Inclusion Criteria: * Diagnosed with Type 2 Diabetes Mellitus (T2DM) for at least 90 days prior to screening * T2DM inadequately managed with lifestyle management alone or on stable treatment with other background glucose-lowering medication(s) * HbA1c value of ≥ 7% to ≤ 10.5% (53 to 91.3 mmol/mol) * Increased risk of cardiovascular (CV) events defined by ≥1 of: documented coronary heart disease, peripheral arterial disease, ischemic cerebrovascular disease, or heart failure (NYHA II-III); or ≥2 CV risk factors * Body mass index (BMI) of ≥ 23 kg/m2 at screening * Stable body weight (self-reported or documented) for 90 days prior to screening Exclusion Criteria: * Type 1 Diabetes Mellitus (T1DM), secondary forms of diabetes (including congenital forms), or history of ketoacidosis or hyperosmolar coma * Currently receiving or anticipated to receive, therapeutic intervention for diabetic retinopathy and/or macular edema * Have had more than one episode of severe hypoglycemia within 180 days prior to screening or has a history of hypoglycemia unawareness or poor recognition of hypoglycemic symptoms * Clinically significant condition affecting the upper Gastrointestinal (GI) tract or chronic use of any medication that affects gastric motility or gastric emptying * History of acute or chronic pancreatitis * Severe congestive heart failure (NYHA IV) * History/family history of medullary thyroid cancer or multiple endocrine neoplasia type 2

Study sites by state

Alabama

  • Research Site, Birmingham · Opening soon

Arizona

  • Research Site, Mesa · Opening soon
  • Research Site, Phoenix · Opening soon
  • Research Site, Tempe · Opening soon

California

  • Research Site, Covina · Opening soon
  • Research Site, Encinitas · Opening soon
  • Research Site, Garden Grove · Opening soon
  • Research Site, Loma Linda · Opening soon
  • Research Site, Long Beach · Opening soon
  • Research Site, Pomona · Opening soon
  • Research Site, Sacramento · Opening soon

Connecticut

  • Research Site, Bridgeport · Opening soon

Florida

  • Research Site, Crystal River · Opening soon
  • Research Site, Hollywood · Opening soon
  • Research Site, Jacksonville · Opening soon
  • Research Site, Leesburg · Opening soon
  • Research Site, Orlando · Opening soon

Georgia

  • Research Site, Lilburn · Opening soon

Idaho

  • Research Site, Idaho Falls · Opening soon

Illinois

  • Research Site, Melrose Park · Opening soon

Indiana

  • Research Site, Evansville · Opening soon

Iowa

  • Research Site, Ames · Opening soon

Kansas

  • Research Site, Wichita · Opening soon

Kentucky

  • Research Site, Bowling Green · Opening soon

Maryland

  • Research Site, Rockville · Opening soon

Michigan

  • Research Site, Southfield · Opening soon

Minnesota

  • Research Site, Minneapolis · Opening soon

Missouri

  • Research Site, Jefferson City · Opening soon
  • Research Site, Kansas City · Opening soon

Nebraska

  • Research Site, Omaha · Opening soon

Nevada

  • Research Site, Henderson · Opening soon
  • Research Site, Las Vegas · Opening soon

New Mexico

  • Research Site, Albuquerque · Opening soon

North Carolina

  • Research Site, Durham · Opening soon
  • Research Site, Morehead City · Opening soon
  • Research Site, Raleigh · Opening soon
  • Research Site, Statesville · Opening soon
  • Research Site, Wilmington · Opening soon

Ohio

  • Research Site, Columbus · Opening soon

Oklahoma

  • Research Site, Yukon · Opening soon

Pennsylvania

  • Research Site, Feasterville-Trevose · Opening soon
  • Research Site, Philadelphia · Opening soon

South Carolina

  • Research Site, Myrtle Beach · Opening soon
  • Research Site, North Charleston · Opening soon

Tennessee

  • Research Site, Memphis · Opening soon
  • Research Site, Morristown · Opening soon

Texas

  • Research Site, Dallas · Opening soon
  • Research Site, Houston · Opening soon
  • Research Site, Houston · Opening soon
  • Research Site, Houston · Opening soon
  • Research Site, Katy · Opening soon
  • Research Site, San Antonio · Opening soon
  • Research Site, San Antonio · Opening soon
  • Research Site, Sugar Land · Opening soon
  • Research Site, Weslaco · Opening soon

Utah

  • Research Site, Bountiful · Opening soon
  • Research Site, Salt Lake City · Opening soon

Virginia

  • Research Site, Leesburg · Opening soon
  • Research Site, Norfolk · Opening soon

Washington

  • Research Site, Renton · Opening soon
  • Research Site, Seattle · Opening soon
  • Research Site, Seattle · Opening soon

West Virginia

  • Research Site, Morgantown · Opening soon

View the official record on ClinicalTrials.gov →

Verify before you act. Medical disclaimer: content on this site is for informational purposes only and is not medical advice. GLP-1 medications are prescription drugs; always consult a licensed healthcare provider about eligibility, risks, and benefits. Trial details and enrollment status change frequently, so always verify on the official registry and talk to your own clinician before contacting a study site. This page was generated from registry data and is not affiliated with the study sponsor.

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