What this trial means for you
This study is opening soon at 46 US sites. It's studying Zenagamtide, Semaglutide, Placebo (matched to semaglutide), Placebo (matched to zenagamtide) for overweight, obesity.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study, ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry. Bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Male or female (sex at birth). * Age 18 years or above at the time of signing the informed consent. Exclusion Criteria: * Glycated haemoglobin (HbA1c) ≥ 6.5% (48 millimoles per mole \[mmol/mol\]) as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues within 1 year before screening.
Study sites by state
California
- First Valley Medical Group, Lancaster
- Desert Oasis Healthcare, Palm Springs
- Western University of Health Sciences, Pomona
- Artemis Insitute for Clin Res, San Diego
District of Columbia
- Med Home Development Grp, Washington D.C.
Florida
- Encore Medical Research LLC, Hollywood
- NextPhase Research, Hollywood
- Jacksonville Ctr Clin Res, Jacksonville
- PharmaDev Clinical Research Institute LLC, Miami
- South Broward Research LLC, Miramar
- Essence MD Research, Naples
- Florida Inst For Clin Res LLC, Orlando
- Oviedo Medical Research, LLC, Oviedo
- Palm Beach Research Center, West Palm Beach
- Encore Medical Research of Weston, Weston
Georgia
- Conquest Research, Atlanta
- Eastside Bariatric and Gen Surg, Snellville
Illinois
- Chicago Research Center, Inc, Chicago
- Endeavor Health, Skokie
Indiana
- Midwest Inst For Clin Res, Indianapolis
Louisiana
- Southern Clin Research, Zachary
Missouri
- Amicis Centers of Clinical Research, St Louis
New York
- Ichor Research, Syracuse
- Southgate Medical Group, LLP, West Seneca
North Carolina
- University of North Carolina, Chapel Hill
- PharmQuest Life Sciences LLC, Greensboro
- Piedmont Healthcare/Research, Statesville
North Dakota
- Lillestol Research LLC, Fargo
Pennsylvania
- Geisinger Clinic, Danville
South Carolina
- Medical University Of South Carolina, Charleston
- Hillcrest Clinical Research, Simpsonville
- Spartanburg Medical Research, Spartanburg
Texas
- Amarillo Med Spec LLP, Amarillo
- Texas Diabetes & Endocrinology, Austin
- Pinnacle Clinical Research, Brownsville
- Osvaldo A. Brusco MD, Corpus Christi
- UT Southwestern Med Center, Dallas
- Epic Medical Research, DeSoto
- Houston Research Institute, Houston
- The Endocrine Center, Houston
- Sleep Therapy Research Center, San Antonio
- Olympus Clinical Research, Sugar Land
Virginia
- National Clin Res Inc., Richmond
- Gastroent Consult of SW VA, Roanoke
Washington
- Rainier Clin Res Ctr Inc, Renton
- Seattle Clinical Research Center, Seattle
View the official record on ClinicalTrials.gov →
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