What this trial means for you
This study is opening soon at 79 US sites. It's studying Orforglipron, Placebo for overweight, prediabetic state, prehypertension.
What participants typically get: study medication (or placebo, if the trial uses one) and study-related medical care at no cost, plus close monitoring. Compensation for time and travel varies by study, ask the site. Note that in many trials you can't choose your treatment group, and some participants receive a placebo.
The study, in the sponsor's words
This study will evaluate the efficacy and safety of orforglipron in participants with overweight and assess whether it helps reduce the future risk of obesity-related conditions, including type 2 diabetes, hypertension, and dyslipidemia, and progression to class 1 obesity.
Can you join? The exact criteria
Below is the verbatim eligibility text from the registry. Bring it to your doctor; it's written for clinicians, and your own clinician is the right person to interpret it with you.
Full eligibility criteria (for you and your doctor)
Inclusion Criteria: * Have an increased waist-to-height ratio of ≥0.5 * Have at least one pre-obesity-related complication (prediabetes, prehypertension, predyslipidemia) * Have at least one unsuccessful attempt to reduce body weight based on diet and exercise * Have a BMI greater than or equal to 25 to less than or equal to 29.9 kg/m2 or equivalent-/region-specific overweight thresholds Exclusion Criteria: * Have type 1 diabetes, type 2 diabetes, or any other type of diabetes * Do not have a stable body weight within 90 days before screening * Have a documented obesity diagnosis or self-reported history of BMI ≥30 kg/m² (or an equivalent region-specific threshold) * Have taken medications for weight loss, including over-the counter medications or alternative therapies, within 180 days prior to screening * Have a prior or planned surgical treatment or procedure for obesity * Have hypertension or history of hypertension * Have dyslipidemia or history of dyslipidemia
Study sites by state
Alabama
- Pinnacle Research Group, LLC, Anniston
- Central Research Associates, Birmingham
- Cahaba Research - Pelham, Pelham
Arizona
- Care Access - 801 South Power Road, Mesa, Mesa
- Absolute Clinical Research, Phoenix
- Synexus Clinical Research US, Inc./Orange Grove Family Practice, Tucson
California
- Orange County Research Center, Lake Forest
- Healthy Brain Clinic, Long Beach
- Los Angeles Institute for Metabolic Research, Los Angeles
- Desert Oasis Healthcare Medical Group, Palm Springs
- Artemis Institute for Clinical Research, Riverside
- Riverside Clinical, Riverside
- Headlands Research- Sacramento, Sacramento
- Norcal Endocrinology & Internal Medicine, San Ramon
- Diablo Clinical Research, Inc., Walnut Creek
Connecticut
- Yale University School of Medicine, New Haven
- Chase Medical Research, LLC, Waterbury
Florida
- Excel Medical Clinical Trials, Boca Raton
- Flourish Research Acquisition, LLC dba Flourish Research - North Miami, Miami
- New Age Medical Research Corporation, Miami
- Renstar Medical Research, Ocala
- Headlands Research Orlando, Orlando
- Oviedo Medical Research, Oviedo
- Care Access - St. Petersburg, St. Petersburg
- Precision Clinical Research, Sunrise
Georgia
- SKY Clinical Research Network Group-Brown, Atlanta
- HOPE Clinical Research & Wellness, Conyers
- Care Access - Dalton Walmart, Dalton
- Care Access - Decatur, Decatur
Idaho
- Family First Medical Center, Idaho Falls
- Solaris Clinical Research, Meridian
Illinois
- Great Lakes Clinical Trials - Ravenswood, Chicago
Iowa
- Iowa Diabetes and Endocrinology Research Center, West Des Moines
Kansas
- Cotton O'Neil Clinical Research Center, Topeka
Kentucky
- Monroe Biomedical Research - Louisville, Louisville
Louisiana
- Pennington Biomedical Research Center, Baton Rouge
- IMA Clinical Research Monroe-Main, Monroe
Maryland
- Centennial Medical Group, Columbia
Massachusetts
- Brigham and Women's Hospital Diabetes Program, Boston
Michigan
- Great Lakes Research Group, Inc., Bay City
- Great Lakes Research Institute, Southfield
- Arcturus Healthcare , PLC, Troy Internal Medicine Research Division, Troy
Minnesota
- Headlands Research-Twin Cities, Maplewood
Missouri
- Clinvest Headlands Llc, Springfield
Nevada
- M3 Wake Research - Las Vegas Cimarron, Las Vegas
- Renascor Clinical Research, Reno
New Jersey
- IMA Clinical Research Warren, Warren Township
New York
- Drug Trials America, Hartsdale
- NYC Research INC, Long Island City
- Rochester Clinical Research, LLC, Rochester
North Carolina
- Medication Management, Greensboro
- West Clinical Research, Morehead City
- Trial Management Associates - Wilmington - Floral Parkway, Wilmington
North Dakota
- Lillestol Research, Fargo
Ohio
- Remington-Davis, Inc, Columbus
Oklahoma
- Central States Research, Tulsa
Oregon
- The Corvallis Clinic, P.C., Corvallis
Pennsylvania
- Clinical Renal Associates Ltd., Media
- Suburban Research Associates, West Chester
South Carolina
- Care Access - Mauldin, Mauldin
Tennessee
- New Phase Research and Development, Knoxville
- Clinical Research Associates Inc, Nashville
Texas
- IMA Clinical Research Austin, Austin
- Headlands Horizons, LLC dba Headlands Research-Brownsville, Brownsville
- Cedar Health Research - Texas Native Health, Dallas
- Headlands Research-El Paso, El Paso
- Cedar Health Research - Euless, Euless
- Biopharma Informatic, LLC, Houston
- Care Access - Houston - Clinical Trials Center by Walmart & Care Access, Houston
- Activian Clinical Research, Kingwood
- DCOL Center for Clinical Research, Longview
- IMA Clinical Research San Antonio, San Antonio
- VIP Trials, San Antonio, TX 78230
- Consano Clinical Research, LLC, Shavano Park
- Care Access - Tyler - Clinical Trials Center by Walmart & Care Access, Tyler
Virginia
- Sovah Clinical Research-River District, Danville
- Clinical Research Partners, LLC, Richmond
West Virginia
- CAMC Institute for Academic Medicine, Charleston
- Frontier Clinical Research, LLC, Kingwood
View the official record on ClinicalTrials.gov →
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